969. Adulteration and misbranding of pituitary solution posterior lobe. U. S. v.
332 Boxes of Pituitary Solution Posterior Lobe. Decree of condemnation
and destruction.    (F. D. C. No. 8885.    Sample No. 29212-F.)
Examination of this product showed that 1 cubic centimeter produced an
activity upon the isolated uterus of the virgin guinea pig corresponding to 160
percent of that produced by 0.005 gram of standard powdered posterior pituitary,
whereas the eleventh revision of the United States Pharmacopoeia, which was
official at the time the goods described were shipped, provided that "One cubic
centimeter of Solution of Posterior Pituitary produces an activity upon the
isolated uterus of the virgin guinea pig, corresponding to * * * not more
than 120 percent of that produced by 0.005 Gm. of the Standard Powdered Pos-
terior Pituitary."
On November 18, 1942, the United States attorney for the Northern District of
Georgia filed a libel against 332 boxes, each containing 6 ampuls, of pituitary
solution posterior lobe at Atlanta, Ga., alleging.that the article had been shipped
or about September 23, 1942, from Detroit, Mich., by Parke, Davis and Co.; and
charging that it was adulterated and misbranded.
The article was alleged to be adulterated in that it purported to be and was
represented as a drug, the name of which was recognized in an official com-
pendium, the United States Pharmacopoeia, Eleventh Revision, but its strength
differed from the standard set forth in such compendium since it produced an
activity in excess of the maximum permitted by the standard set forth therein.
It was alleged to be misbranded in that the statement appearing in its label-
ing "Pituitary Solution, Posterior Lobe, U. S. P." was false and misleading as
applied to the article since its potency was greater than the maximum permitted
by the United States Pharmacopoeia, Eleventh Revision.
On April 12, 1943, no claimant having appeared, judgment of condemnation
was entered and the product was ordered destroyed.