21806. Adulteration and misbranding of granular effervescent sodium 
phosphate, elixir three bromides, fluidextract of ipecac, tincture 
of belladonna, and aromatic spirit of ammonia. J. S. v. Hance 
Bros.  & White, Inc.     Plea  of nolo contendere.     Fine, $75.      (F.  &
D. no. 30218.    Sample nos. 10749-A, 11427-A, 21273-A, 21274-A, 21631-A.)
This case was based on interstate shipments of granular effervescent sodium 
phosphate, fluidextract of ipecac, tincture of belladonna, and aromatic spirit 
of ammonia, products which are recognized in the United States Pharmaco- 
poeia and which were labeled as being of pharmacopoeial standard; also of a 
shipment of elixir three bromides, a product which is recognized in the Nation- 
al Formulary and which was labeled as being a formulary standard. Analy- 
ses of the articles showed that they failed to conform to the tests laid down in 
the said authorities.
On December 27, 1933, the United States attorney for the Eastern District 
of Pennsylvania, acting upon a report by the Secretary of Agriculture, filed in 
the district court an information against Hance Bros. & White, Inc., Philadel- 
phia, Pa., alleging shipment by said company ,in violation of the Food and 
Drugs Act, on or about January 5, January 16, and February 4, 1932, from the 
State of Pennsylvania into the State of New Jersey, of quantities of granular 
effervescent sodium phosphate; on or about March 3 and November 22, 1932, 
from the State of Pennsylvania into the State of New York, of quantities of 
elixir three bromides, fluidextract of ipecac, and tincture of belladonna; and 
on or about January 10, 1933, from the State of Pennsylvania into the State of 
Connecticut, of a quantity of aromatic spirit of ammonia, which was adulter- 
ated and misbranded. The articles were labeled in part, variously: "I.D.A. 
Granular Effervescent Sodium Phosphate * * * U.S.P. Strength * * * 
Packed for Independent Druggists Alliance Distributing Company, Chicago, 
111."; "Elixir Three Bromides N.F. * * * Hance Brothers & White, In- 
corporated " ; " Fluidextract Ipecac U.S.P. Each 100 Cc contains not less than 
1.35 Gms. or more than 1.65 Gms. of Ether Soluble Alkaloids of Ipecac " ; " Tinc- 
ture Belladonna U.S.P.-X. * * * Each 100 Cc. contains not less than .027 
gm. or more than .033 gm. of the alkaloids of Belladonna Leaves "; " Aromatic 
Spirit Ammonia U.S.P.-X." 
moist   i >
It was alleged in the information that the elixir three bromides was adul- 
terated in that it was sold under a name recognized in the National Formulary,
and differed from the standard of strength, quality, and purity as determined 
by the tests laid down in the said formulary official at the time of investiga- 
tion, since it contained not more than 70.12 grams of potassium bromide and not 
more than 66.58 grams of sodium bromide, per 1,000 cubic centimeters, where- 
as the National Formulary provides that 1,000 cubic centimeters of elixir three 
bromides shall contain not less than 80 grams each of potassium bromide and 
sodium bromide; and the standard of strength, quality, and purity of the 
article was not declared on the container.
Adulteration of the remaining products was alleged for the reason that they 
were sold under names recognized in the United States Pharmacopoeia and 
differed from the standard of strength, quality, and purity as determined by 
the tests laid down in the said pharmacopoeia, in the following respects, and 
their own standard of strength, quality, and purity was not declared on the 
container: The granular effervescent sodium phosphate contained more than 
20 percent of exsiccated sodium phosphate, namely, not less than 32.46 percent 
of exsiccated sodium phosphate, whereas the pharmacopoeia provides that the 
product shall contain not more than 20 percent of exsiccated sodium phosphate; 
the fluidextract of ipecac yielded less than 1.35 grams, namely, not more than 
1.027 grams, of the ether-soluble alkaloids of ipecac per 100 cubic centimeters, 
whereas the pharmacopoeia provides that the product shall yield from each 
100 cubic centimeters not less than 1.35 grams of the ether-soluble alkaloids of 
ipecac; the tincture of belladonna yielded more than 0.033 gram, namely, not 
less than 0.037 gram, of the alkaloids of belladonna leaves per 100 cubic centi- 
meters, whereas the pharmacopoeia provides that the product shall contain in 
each 100 cubic centimeters not more than .033 gram of the alkaloids of belladonna 
leaves; the aromatic spirit of ammonia contained less than 1.839 grams, namely, 
not more than 1.171 grams, of ammonia per 100 cubic centimeters, whereas the 
pharmacopoeia provides that the product shall contain not less than 1.839 
grams of ammonia per 100 cubic centimeters. Adulteration was alleged with 
respect to all products for the further reason that their strength and purity fell 
below the professed standard and quality under which they were sold.
Misbranding was alleged for the reason that the statements "Effervescent 
Sodium Phosphate .* * * U.S.P. Strength", "Elixir Three Bromides, 
N.F.", " Fluidextract Ipecac, U.S.P. Each 100 Cc. contains not less than 1.35 
Gms. or more than 1.65 Gms. of Ether Soluble Alkaloids of Ipecac ". " Tincture 
Belladonna U.S.P.-X * * * Each 100 Cc. contains not * * * more 
than .033 gm. of the Alkaloids of Belladonna Leaves ", "Aromatic Spirit Ammonia 
U.S.P.-X ", borne on the labels of the respective products, were false and mis- 
leading.
On January 22, 1934. a plea of nolo contendere was entered on behalf of the 
defendant company, and the court imposed a fine of $75.
M. L. WILSON, Actinff Secretary of Agriculture.